In 1967, Mester accidentally discovered that low-intensity ruby laser (wavelength 690nm) not only has no carcinogenic effect, but can promote hair growth.
Research has confirmed that LLLT can increase the synthesis of reactive oxygen species (ROS), enhance the cellular oxidation reaction ability, and cause changes in the redox potential of the entire cell, activating a variety of signal transduction. The spectrum used in the experiment is between 630nm-660nm.
Among them, nuclear transcription factor-κB (Nuclear factor kappa B, NF-κB) can regulate the synthesis and secretion of a variety of cytokines, inflammatory mediators and growth factors, and these growth factors make cells including epithelial cells, endothelial cells, keratinocytes, lymphocytes, fibroblasts proliferate and promote collagen synthesis, angiogenesis, granulation formation, thereby accelerating wound healing.
At the same time, LLLT promotes the local generation or release of NO, activates cytochrome C oxidase and restores cell respiration, and increases ATP generation.
NO can stimulate vasodilation by acting on c GMP, thereby improving local microcirculation, increasing oxygen supply, relieving inflammatory response and the accompanying swelling and pain, and promoting wound healing.
Therefore, red light (energy density 4.5J/cm2) effectively regulates the inflammatory response of deep second-degree burn wounds and has a good healing effect, which opens up a new way for wound repair and may have a good application prospect.
Below are some research reports on the promotion of burn wounds by photobiological conditions. For the specific report content, you can click the link below to view it.
https://www.nature.com/articles/s41598-021-92650-w
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